Targeting Cutaneous Cannabinoid Signaling in Inflammation - A “High”-way to Heal?

Article history: Received 28 November 2016 Received in revised form 29 December 2016 Accepted 4 January 2017 Available online 7 January 2017 (Karsak et al., 2007). Moreover, AEA was recently shown to suppress production and release of key Th1and Th17-polarizing cytokines (IL12 and IL-23) via CB1-mediated inhibition of mammalian target of rapamycin (mTOR) in human keratinocytes (Chiurchiù et al., 2016). Collectively, these findings (together with many other recently published data) implied keratinocytes to be “non-classical” immune competent cells, playing a central role in initiation and regulation of